ANTI-AGING

Potential Breakthrough Treatment for Erectile Dysfunction

Futura Medical’s fast-acting topical erectile dysfunction drug MED2005 shows potential as a first-line treatment, following publication of Phase II trial data in the Journal of Sexual Medicine. MED2005 delivers encouraging results with rapid onset of action, significant improvements in Erectile Function scores, and a favourable safety profile

Futura Medical today announced the publication of a Phase II trial of MED2005 in erectile dysfunction (ED) in the Journal of Sexual Medicine.1 MED2005 is a topical gel applied directly to the glans of the penis that contains 0.2% w/w glyceryl trinitrate and DermaSys® technology, an enhanced topical absorption system that facilitates rapid drug delivery across the skin barrier.

The Phase II trial of 230 men with confirmed ED demonstrated that treatment with MED2005 significantly improved their International Index of Erectile Function-Erectile Function (IIEF-EF) score, the gold standard for efficacy measures in ED2 (p=0.0132). Onset of erection occurred within 10 minutes for 70% of participants on average. MED2005 was very well tolerated with no reported serious adverse events related to the treatment in men or their partners, and no withdrawals from the study due to adverse events.

Futura Medical, a pharmaceutical company that focuses on innovative transdermal drug delivery technology, is developing a portfolio of sexual health products with a view to licensing the sales and marketing of these products to major pharmaceutical and healthcare groups.

James Barder CEO, Futura Medical said: “We are extremely encouraged by this Phase II data and in particular the rapid onset of MED2005 which can help restore spontaneity and greater intimacy for men with erectile dysfunction. The excellent safety profile allows us to explore higher dose levels to optimise the efficacy and safety profile of the product. We are also actively continuing our discussions to find the right licensing partner for this exciting product.”

Professor David Ralph Consultant Urologist at St Peter’s Andrology Centre & Institute of Urology, UCLH, London, past President of the European Society of Sexual Medicine, and study author said: “MED2005 has the required efficacy, speed of onset and safety profile consistent for an over-the-counter as well as prescription use product. MED2005, for the first time in the treatment of ED, has the potential to meet the needs of primary care providers and of patients.”

During 2018 Futura Medical will commence a Phase III trial programme to evaluate the safety and efficacy profile of the product at varying dose levels in a larger patient population. Higher doses will be trialled to improve the clinical significance in cases of moderate and severe ED.

Everything You Need to Know About Erectile Dysfunction (ED)

What is erectile dysfunction (ED)?

Erectile dysfunction (ED) is the inability to get or keep an erection firm enough to have sexual intercourse. It’s also sometimes referred to as impotence.

Occasional ED isn’t uncommon. Many men experience it during times of stress. Frequent ED can be a sign of health problems that need treatment. It can also be a sign of emotional or relationship difficulties that may need to be addressed by a professional.

Not all male sexual problems are caused by ED. Other types of male sexual dysfunction include:

premature ejaculation

delayed or absent ejaculation

lack of interest in sex

What are the symptoms of ED?

You may have erectile dysfunction if you regularly have:

trouble getting an erection

difficulty maintaining an erection during sexual activities

reduced interest in sexOther sexual disorders related to ED include:

premature ejaculation

delayed ejaculation

anorgasmia, which is the inability to achieve orgasm after ample stimulation。

You should talk to your doctor if you have any of these symptoms, especially if they’ve lasted for two or more months. Your doctor can determine if your sexual disorder is caused by an underlying condition that requires treatment.

What causes ED?

There are many possible causes for ED, and they can include both emotional and physical disorders. Some common causes are:

cardiovascular disease

diabetes

hypertension

hyperlipidemia

damage from cancer or surgery

injuries

obesity or being overweight

increased age

stress

anxiety

relationship problems

drug use

alcohol use

smokingED can be caused by only one of these factors or several. That’s why it’s important to work with your doctor so that they can rule out or treat any underlying medical conditions.

What causes an erection?

An erection is the result of increased blood flow into your penis. Blood flow is usually stimulated by either sexual thoughts or direct contact with your penis.

When a man becomes sexually excited, muscles in their penis relax. This relaxation allows for increased blood flow through the penile arteries. This blood fills two chambers inside the penis called the corpora cavernosa. As the chambers fill with blood, the penis grows rigid. Erection ends when the muscles contract and the accumulated blood can flow out through the penile veins.

ED can occur because of problems at any stage of the erection process. For example, the penile arteries may be too damaged to open properly and allow blood in.

How does age affect incidence of ED?

Up to 30 million American men are affected by ED, according to the National Institute of Diabetes and Digestive and Kidney Diseases. The prevalence of ED increases with age. ED affects:

12 percent of men younger than 60

22 percent of men in their 60s

30 percent of men 70 or olderAlthough the risk of ED increases with age, ED is not inevitable as you get older. It may be more difficult to get an erection as you age, but that doesn’t necessarily mean you will develop ED. In general, the healthier you are, the better your sexual function.

ED can also occur among younger men. A 2013 study found that one in four men seeking their first treatment for ED were under the age of 40. The researchers found a stronger correlation between smoking and illicit drug use and ED in men under 40 than among older men. That suggests that lifestyle choices may be a main contributing factor for ED in younger men.

An analysis of research on ED in men under 40 found that smoking was a factor for ED among 41 percent of men under the age of 40. Diabetes was the next most common risk factor and was linked to ED in 27 percent of men under 40.

How is ED diagnosed?

Your doctor will ask you questions about your symptoms and health history. They may do tests to determine if your symptoms are caused by an underlying condition. You should expect a physical exam where your doctor will listen to your heart and lungs, check your blood pressure, and examine your testicles and penis. They may also recommend a rectal exam to check your prostate. Additionally, you may need blood or urine tests to rule out other conditions.

Nocturnal penile tumescence (NPT) test

An NPT test is done using a portable, battery-powered device that you wear on your thigh while you’re sleeping. The device evaluates the quality of nocturnal erections and stores the data, which your doctor can later access. Your doctor can use this data to better understand your penis function and ED.

Nocturnal erections are erections that occur while you’re sleeping, and they’re a normal part of a healthily functioning penis.

What treatments are available?

Treatment for ED will depend on the underlying cause. You may also need to use a combination of treatments, including medication, lifestyle changes, or therapy.

ED medications

Your doctor may prescribe medication to help manage your symptoms of ED. You may need to try several medications before you find one that works. These medications can have side effects. If you’re experiencing unpleasant side effects, talk to your doctor. They may be able to recommend a different medication.

The following medications stimulate blood flow to your penis to help treat ED:

alprostadil (Caverject)

avanafil (Stendra)

sildenafil (Viagra)

tadalafil (Cialis)

testosterone (Androderm)

vardenafil (Levitra)

Natural remedies and herbs for ED

For some men, natural remedies may help treat ED. Talk to your doctor before trying a new supplement or herb.

You should also use caution when buying supplements and herbs. Many aren’t regulated, which means they may contain additional ingredients not listed on the labels. Ask your doctor to recommend reputable brands and avoid purchasing supplements online.

The following herbs and supplements have been shown to have varying degrees of success for the treatment of ED:

L-arginine

DHEA

ginseng

yohimbe

Asparagus racemosus

Talk therapy

Psychological factors are a common cause of ED, including:

stress

anxiety

post-traumatic stress disorder (PTSD)

depression

If you’re experiencing psychological ED, you may benefit from talk therapy. Therapy can help you manage your mental health. You’ll likely work with your therapist over several sessions, and your therapist will address things like major stress or anxiety factors, feelings around sex, or subconscious conflicts that could be affecting your sexual well-being.

If ED is affecting your relationship, you may also consider speaking with a relationship counselor. Relationship counseling can help you reconnect emotionally with a partner, which may also help your ED.

Alternative treatments

If your ED is caused by stress, yoga and massage may help if you find these activities relaxing.

Prostatic massage

Some men use a form of massage therapy called prostatic massage. Practitioners massage the tissues in and around your groin to promote blood flow to your penis. There are limited studies on the efficacy of this type of massage.

Acupuncture

Acupuncture may help treat psychological ED, though studies are limited and inconclusive. You’ll likely need several appointments before you begin to notice any improvements. When choosing an acupuncturist, look for a certified practitioner who uses disposable needles and follows U.S. Food and Drug Administration guidelines for needle disposal and sterilization.

Pelvic floor muscle exercises

A small study of 55 men saw improvement to penile function after three months of regular pelvic floor muscles exercises, and after six months, 40 percent of men had regained normal erectile function.

Kegel exercises are a simple exercise you can use to strengthen your pelvic floor muscles. Here’s how you do them:

Identify your pelvic floor muscles. To do this, stop peeing midstream. The muscles you use to do this are your pelvic floor muscles. Your testicles will also rise when you contract these muscles.

Now that you know where these muscles are, contract them for 5 to 20 seconds. Then release them.

Repeat this exercise 10 to 20 times in a row, three to four times a day.

Lifestyle changes and diet

Healthy lifestyle habits may prevent ED, and in some situations reverse the condition:

Exercise regularly.

Maintain a low blood pressure.

Eat a balanced, nutritious diet.

Maintain a healthy weight.

Avoid alcohol and cigarettes.

Reduce your stress.

ED is often related to problems with your blood flow, so maintaining your blood vessel health through exercise and a healthy diet may help reduce your risk for ED.

Change your medications

In some cases, medications used to treat other conditions may cause ED. Talk to your doctor about medications you’re taking and whether they could be causing your symptoms. There may be other medications you can take instead.

Don’t stop taking medications without first talking to your doctor.

Is ED reversible?

In many cases, you can improve your symptoms of ED. Many medications and treatments are available. As well, certain devices, like an erectile dysfunction pump or erectile dysfunction ring, may help temporarily manage symptoms of ED so that you can continue to engage in sexual intercourse.

ED is a common condition, and it has many possible causes. Discuss your symptoms with your doctor early so that they can rule out underlying causes and begin a treatment plan.

Find Out if You Have Low Testosterone

Maintaining hormone levels is key to staying healthy over everyone’s lifetime. Symptoms of low testosterone can be treated and more serious complications can be caught early when you test your testosterone.

SAVE 15% ON YOUR FIRST TEST

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Medically reviewed by Alana Biggers, MD on May 17, 2017 — Written by the Healthline Editorial Team

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Potential Breakthrough Treatment for Erectile Dysfunction

Futura Medical’s fast-acting topical erectile dysfunction drug MED2005 shows potential as a first-line treatment, following publication of Phase II trial data in the Journal of Sexual Medicine. MED2005 delivers encouraging results with rapid onset of action, significant improvements in Erectile Function scores, and a favourable safety profile

Futura Medical today announced the publication of a Phase II trial of MED2005 in erectile dysfunction (ED) in the Journal of Sexual Medicine.1 MED2005 is a topical gel applied directly to the glans of the penis that contains 0.2% w/w glyceryl trinitrate and DermaSys® technology, an enhanced topical absorption system that facilitates rapid drug delivery across the skin barrier.

The Phase II trial of 230 men with confirmed ED demonstrated that treatment with MED2005 significantly improved their International Index of Erectile Function-Erectile Function (IIEF-EF) score, the gold standard for efficacy measures in ED2 (p=0.0132). Onset of erection occurred within 10 minutes for 70% of participants on average. MED2005 was very well tolerated with no reported serious adverse events related to the treatment in men or their partners, and no withdrawals from the study due to adverse events.

Futura Medical, a pharmaceutical company that focuses on innovative transdermal drug delivery technology, is developing a portfolio of sexual health products with a view to licensing the sales and marketing of these products to major pharmaceutical and healthcare groups.

James Barder CEO, Futura Medical said: “We are extremely encouraged by this Phase II data and in particular the rapid onset of MED2005 which can help restore spontaneity and greater intimacy for men with erectile dysfunction. The excellent safety profile allows us to explore higher dose levels to optimise the efficacy and safety profile of the product. We are also actively continuing our discussions to find the right licensing partner for this exciting product.”

Professor David Ralph Consultant Urologist at St Peter’s Andrology Centre & Institute of Urology, UCLH, London, past President of the European Society of Sexual Medicine, and study author said: “MED2005 has the required efficacy, speed of onset and safety profile consistent for an over-the-counter as well as prescription use product. MED2005, for the first time in the treatment of ED, has the potential to meet the needs of primary care providers and of patients.”

During 2018 Futura Medical will commence a Phase III trial programme to evaluate the safety and efficacy profile of the product at varying dose levels in a larger patient population. Higher doses will be trialled to improve the clinical significance in cases of moderate and severe ED.

Everything You Need to Know About Erectile Dysfunction (ED)

What is erectile dysfunction (ED)?

Erectile dysfunction (ED) is the inability to get or keep an erection firm enough to have sexual intercourse. It’s also sometimes referred to as impotence.

Occasional ED isn’t uncommon. Many men experience it during times of stress. Frequent ED can be a sign of health problems that need treatment. It can also be a sign of emotional or relationship difficulties that may need to be addressed by a professional.

Not all male sexual problems are caused by ED. Other types of male sexual dysfunction include:

premature ejaculation

delayed or absent ejaculation

lack of interest in sex

What are the symptoms of ED?

You may have erectile dysfunction if you regularly have:

trouble getting an erection

difficulty maintaining an erection during sexual activities

reduced interest in sexOther sexual disorders related to ED include:

premature ejaculation

delayed ejaculation

anorgasmia, which is the inability to achieve orgasm after ample stimulation。

You should talk to your doctor if you have any of these symptoms, especially if they’ve lasted for two or more months. Your doctor can determine if your sexual disorder is caused by an underlying condition that requires treatment.

What causes ED?

There are many possible causes for ED, and they can include both emotional and physical disorders. Some common causes are:

cardiovascular disease

diabetes

hypertension

hyperlipidemia

damage from cancer or surgery

injuries

obesity or being overweight

increased age

stress

anxiety

relationship problems

drug use

alcohol use

smokingED can be caused by only one of these factors or several. That’s why it’s important to work with your doctor so that they can rule out or treat any underlying medical conditions.

What causes an erection?

An erection is the result of increased blood flow into your penis. Blood flow is usually stimulated by either sexual thoughts or direct contact with your penis.

When a man becomes sexually excited, muscles in their penis relax. This relaxation allows for increased blood flow through the penile arteries. This blood fills two chambers inside the penis called the corpora cavernosa. As the chambers fill with blood, the penis grows rigid. Erection ends when the muscles contract and the accumulated blood can flow out through the penile veins.

ED can occur because of problems at any stage of the erection process. For example, the penile arteries may be too damaged to open properly and allow blood in.

How does age affect incidence of ED?

Up to 30 million American men are affected by ED, according to the National Institute of Diabetes and Digestive and Kidney Diseases. The prevalence of ED increases with age. ED affects:

12 percent of men younger than 60

22 percent of men in their 60s

30 percent of men 70 or olderAlthough the risk of ED increases with age, ED is not inevitable as you get older. It may be more difficult to get an erection as you age, but that doesn’t necessarily mean you will develop ED. In general, the healthier you are, the better your sexual function.

ED can also occur among younger men. A 2013 study found that one in four men seeking their first treatment for ED were under the age of 40. The researchers found a stronger correlation between smoking and illicit drug use and ED in men under 40 than among older men. That suggests that lifestyle choices may be a main contributing factor for ED in younger men.

An analysis of research on ED in men under 40 found that smoking was a factor for ED among 41 percent of men under the age of 40. Diabetes was the next most common risk factor and was linked to ED in 27 percent of men under 40.

How is ED diagnosed?

Your doctor will ask you questions about your symptoms and health history. They may do tests to determine if your symptoms are caused by an underlying condition. You should expect a physical exam where your doctor will listen to your heart and lungs, check your blood pressure, and examine your testicles and penis. They may also recommend a rectal exam to check your prostate. Additionally, you may need blood or urine tests to rule out other conditions.

Nocturnal penile tumescence (NPT) test

An NPT test is done using a portable, battery-powered device that you wear on your thigh while you’re sleeping. The device evaluates the quality of nocturnal erections and stores the data, which your doctor can later access. Your doctor can use this data to better understand your penis function and ED.

Nocturnal erections are erections that occur while you’re sleeping, and they’re a normal part of a healthily functioning penis.

What treatments are available?

Treatment for ED will depend on the underlying cause. You may also need to use a combination of treatments, including medication, lifestyle changes, or therapy.

ED medications

Your doctor may prescribe medication to help manage your symptoms of ED. You may need to try several medications before you find one that works. These medications can have side effects. If you’re experiencing unpleasant side effects, talk to your doctor. They may be able to recommend a different medication.

The following medications stimulate blood flow to your penis to help treat ED:

alprostadil (Caverject)

avanafil (Stendra)

sildenafil (Viagra)

tadalafil (Cialis)

testosterone (Androderm)

vardenafil (Levitra)

Natural remedies and herbs for ED

For some men, natural remedies may help treat ED. Talk to your doctor before trying a new supplement or herb.

You should also use caution when buying supplements and herbs. Many aren’t regulated, which means they may contain additional ingredients not listed on the labels. Ask your doctor to recommend reputable brands and avoid purchasing supplements online.

The following herbs and supplements have been shown to have varying degrees of success for the treatment of ED:

L-arginine

DHEA

ginseng

yohimbe

Asparagus racemosus

Talk therapy

Psychological factors are a common cause of ED, including:

stress

anxiety

post-traumatic stress disorder (PTSD)

depression

If you’re experiencing psychological ED, you may benefit from talk therapy. Therapy can help you manage your mental health. You’ll likely work with your therapist over several sessions, and your therapist will address things like major stress or anxiety factors, feelings around sex, or subconscious conflicts that could be affecting your sexual well-being.

If ED is affecting your relationship, you may also consider speaking with a relationship counselor. Relationship counseling can help you reconnect emotionally with a partner, which may also help your ED.

Alternative treatments

If your ED is caused by stress, yoga and massage may help if you find these activities relaxing.

Prostatic massage

Some men use a form of massage therapy called prostatic massage. Practitioners massage the tissues in and around your groin to promote blood flow to your penis. There are limited studies on the efficacy of this type of massage.

Acupuncture

Acupuncture may help treat psychological ED, though studies are limited and inconclusive. You’ll likely need several appointments before you begin to notice any improvements. When choosing an acupuncturist, look for a certified practitioner who uses disposable needles and follows U.S. Food and Drug Administration guidelines for needle disposal and sterilization.

Pelvic floor muscle exercises

A small study of 55 men saw improvement to penile function after three months of regular pelvic floor muscles exercises, and after six months, 40 percent of men had regained normal erectile function.

Kegel exercises are a simple exercise you can use to strengthen your pelvic floor muscles. Here’s how you do them:

Identify your pelvic floor muscles. To do this, stop peeing midstream. The muscles you use to do this are your pelvic floor muscles. Your testicles will also rise when you contract these muscles.

Now that you know where these muscles are, contract them for 5 to 20 seconds. Then release them.

Repeat this exercise 10 to 20 times in a row, three to four times a day.

Lifestyle changes and diet

Healthy lifestyle habits may prevent ED, and in some situations reverse the condition:

Exercise regularly.

Maintain a low blood pressure.

Eat a balanced, nutritious diet.

Maintain a healthy weight.

Avoid alcohol and cigarettes.

Reduce your stress.

ED is often related to problems with your blood flow, so maintaining your blood vessel health through exercise and a healthy diet may help reduce your risk for ED.

Change your medications

In some cases, medications used to treat other conditions may cause ED. Talk to your doctor about medications you’re taking and whether they could be causing your symptoms. There may be other medications you can take instead.

Don’t stop taking medications without first talking to your doctor.

Is ED reversible?

In many cases, you can improve your symptoms of ED. Many medications and treatments are available. As well, certain devices, like an erectile dysfunction pump or erectile dysfunction ring, may help temporarily manage symptoms of ED so that you can continue to engage in sexual intercourse.

ED is a common condition, and it has many possible causes. Discuss your symptoms with your doctor early so that they can rule out underlying causes and begin a treatment plan.

Find Out if You Have Low Testosterone

Maintaining hormone levels is key to staying healthy over everyone’s lifetime. Symptoms of low testosterone can be treated and more serious complications can be caught early when you test your testosterone.

SAVE 15% ON YOUR FIRST TEST

Article resources

Email this page

Your full name

Your email

Recipient’s email

SEND EMAIL

Your privacy is important to us

FEEDBACK:

How helpful was it?

This article changed my life!

This article was informative.

I have a medical question.

How can we improve it?

This article contains incorrect information.

This article doesn’t have the information I’m looking for.

I have a medical question.

Medically reviewed by Alana Biggers, MD on May 17, 2017 — Written by the Healthline Editorial Team

top stories

NUTRITION

Is Keto Diet Better Than Regular Diet, Even With Exercise?

NUTRITION

5 Possible Side Effects of Probiotics

TECHNOLOGY

Synthetic Ovaries Could Help Treat Menopause

GENERAL HEALTH

Parasite Reportedly Killing Vietnam Vets, 40 Years Later

DIABETES

Will Needle-Less Device Make Life Easier for People With Diabetes?

One of the most common concerns for those who shop for beauty products is how to find the best wrinkle cream that will effectively battle the signs of aging. With so many anti wrinkle creams on the market making a number of different claims, it can be difficult to know which product is the most effective. While many people are on the lookout for a facelift in a jar, the truth is that the most effective anti wrinkle products usually contain clinical grade ingredients at higher concentrations. Moreover, it comes down to the ingredients that will benefit your specific skin type and individual skin concerns. In this article, we discuss what causes wrinkles, how wrinkle creams work and highlight the best wrinkle cream in 2017.

Advanced Dermatology is our most recommended product. Celebrities like  Show…

Woman trying wrinkle cream on face and neckThere are thousands of products that claim to be the most effective, and turn back the clock without surgery. Unfortunately, most of these wrinkle creams contain poor formulas that were developed over a decade ago, and do little more than hydrate the skin. We know that ingredients like peptides, stem cells, growth factors and antioxidants can smooth out wrinkles, and turn back the clock. Whilst there are a handful of products that combine these cutting edge ingredients, they most fail to incorporate a high enough concentration due to the high cost of these ingredients. However, there is one range that features the most cutting edge ingredients at highly active concentrations.

Far more than a wrinkle cream, this revolutionary range regenerates the skin at the deepest layers to target all the visible signs of aging. Have you tried anti wrinkle creams that don’t work? Did you know that most wrinkle creams contain a mere 2-5% active ingredients? This revolutionary range contains 80%+ active ingredients to target even the most tenacious wrinkles. You can try there products risk free with their 30 day money back guarantee.

They offer free shipping in the US and Canada.

The Causes of Wrinkles

People who are on the lookout for the best wrinkle cream on the market often end up buying product after product because they purchase creams and serums that are not made for the wrinkles they are trying to get rid of. In order to prevent this, you should understand what’s causing wrinkles so that you can target them more effectively. For example, fine lines and wrinkles around the eyes are usually caused by laughing, frowning, and other facial expressions that stretch the skin and cause it to fold and wrinkle over time. Forehead wrinkles are often created in this manner. HGTV Fixer Upper Skin Care Anti-Aging Wrinkle Cream, Wrinkle Products, skincare makeup routine  products

Wrinkles are also caused by the natural aging process, when skin begins to thin out and lose collagen. Elastin, a natural protein in the skin, also begins to disintegrate, causing sagging skin and wrinkles on the hands and neck. The best wrinkle creams contain a high concentration of active ingredients that target the skin at the deepest layers to regenerate the skin at a cellular level.

How Anti Wrinkle Creams Work

When you’re considering an anti wrinkle cream for your skin type, you should also understand how the ingredients work. Avoid products that claim to “boost elastin growth,” as the human body is believed to stop elastin production just before puberty. Instead, look for products that combat dryness, which is major contributor to wrinkles.

The best products for fighting fine lines and wrinkles will use a number of ingredients, such as vitamin C, to help the skin boost collagen production so that the body fills them in on their own, without costly or painful injections. Keep in mind that the best wrinkle cream will be one that gives you steady results over a long period of time, not one that works just overnight.

Ingredients

One of the most effective ways to comparison shop and find the best wrinkle cream is to read the ingredients list on the label. Less expensive products will usually have a smaller percentage of anti aging ingredients, older formulas hydrate skin but are unable to boosts collagen production. Stem cells also encourages new cell production, which helps skin look younger.

Another way to ensure that you’re purchasing the best products is to buy one that contains peptides. These chains of amino acids replace lost collagen by sending chemical signals to the body that increases the protein production. Keep in mind that wrinkle creams that contain these ingredients are likely to cost you more.

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Side Effects

Don’t forget that even the highest rated products may have some side effects, so it’s best to consult your dermatologist and discuss your medical history before you start to use a treatment. Some side effects that are common with these creams are stinging, temporary redness, peeling at the application site, and itching. Shopping for the best wrinkle cream may seem daunting at first, but when you understand how wrinkles form and which ingredients will best combat them, you’ll be able to treat them more effectively.

More About Wrinkle Creams

Wrinkles are progressive. The longer you wait, the worse things get. And the more difficult it becomes to reverse facial wrinkles. Can over the counter creams really help smooth out and repair wrinkles? The short answer is yes. Anti Wrinkle creams and other anti aging products, such as serums. have come very far in the last few years. There are many products that are proven to work. But while products offer some in reversing visible signs of aging, experts caution that there’s no miracle product out there to automatically turn back the clock.

Wrinkles are caused by a combination of factors – the sun, genetics, diet and facial movements- however, the main culprit is the breakdown of collagen or elastin. A combination of these factors cause wrinkles to appear on the face. You’re probably here because you want to find the top wrinkle cream and use a product that is proven to achieve good results. A visit to those shelves at your local Macy’s or Sephora or drug store and you’re guaranteed to feel overwhelmed by the number of anti wrinkle products.

Neutrogena promises “Fade the look of stubborn deep wrinkles, including crow’s feet, forehead & cheek wrinkles” so that “in 4 weeks wrinkles are reduced.” L’oreal claims to “address 3 dimensions that visibly age skin: 1. Fight Wrinkles 2. Re-Firm Contours 3. Replenish Facial Volume” Olay claims to “Reverses the look of up to 10 years of wrinkles”. Roc “combines 3 powerful anti-wrinkle technologies to boost cell regeneration* and to reduce the appearance of even deep wrinkles”. Clinique claims to “Help rebuild elasticity and firmness, helps visibly smooth out “laugh lines”.

Today, dermatologist and skin care experts do not recommend many products marketed as wrinkle creams because of a lack of scientific evidence. In fact, most of these professionals recommend prescription products and very few dermatologists recommend over the counter products. However, there are many proven wrinkle creams available today, and in the last few years there has been significant development in products that can stop breakdown of and replenish collagen or elastin.

How to Choose the Best Wrinkle Cream

One of the most common issues concerning skin care today is the treatment and prevention of wrinkles, and if you’re trying to treat crow’s feet, smile and frown lines, or forehead wrinkles, you may be searching for the best wrinkle cream to minimize or erase them completely. However, before you begin your search, you should know that not all wrinkles are the same and the ingredients contained in a wrinkle cream are not formulated to treat all types of wrinkles. For example, some wrinkles form due to loss of collagen and effects of gravity, while others may appear due to repetitive facial expressions and muscle movements. In order to find the best product, you must first understand what type of wrinkles you are trying to treat, what ingredients will be most effective, or if you need to consider other treatment options when creams aren’t the answer.

The Best Wrinkle Cream for Crow’s Feet

One of the most common types of wrinkle is crow’s feet, which are also sometimes known as laugh lines. These are the lines that appear at the corners of your eyes and that develop through repeated muscle contractions as a result of laughing, smiling, and frowning. The depth of these wrinkles may also vary depending on age, the condition of your skin, and how often the skin is exposed to the sun without protection. The best anti wrinkle cream to combat these types of wrinkles is one that contains peptides. These peptides, which contain long chains of amino acids, are absorbed by the skin and help to repair and boost collagen regrowth, which in turn firms the skin. Remember that the best topical products for crow’s feet will probably contain a number of peptide combinations, with palmitoyl pentapeptide being the most common.

The Best Wrinkle Cream for Neck Wrinkles

Neck wrinkles become more common as you age or if you expose your skin to the sun without SPF protection. In some cases, the skin of your neck may take on a thin or crepey appearance. There are a number of wrinkle creams that will treat this problem, but the best wrinkle cream products for neck wrinkles are those that contain retinol. Retinol, which is also known as vitamin A, has been proven to reduce the appearance of fine lines and wrinkles by boosting cell turnover, allowing the skin to shed cells faster and reveal new growth underneath. New skin cells also contain new, healthy collagen fibers, which helps to tighten skin. The best wrinkle cream for neck wrinkles is one that is applied at night, so the retinol has time to be absorbed by the skin and so you do not experience sun sensitivity, which is a common side effect with products that contain this ingredient.

The Best Wrinkle Cream for Forehead Wrinkles

If you’re trying to treat forehead wrinkles, then the best wrinkle cream would be one that contains peptides and collagen stimulants. While most collagen contained in anti wrinkle products on the market can’t penetrate the skin at deeper levels, collagen stimulating ingredients can help your body build more collagen naturally. While this may not provide immediate results, using a wrinkle cream that contains a blend of peptides as well as collagen will ease the appearance of forehead wrinkles over time, with regular use.

Additional Considerations

When you’re comparing the highest rated wrinkle creams on the market, you should consider your own individual skin type and the depth of your forehead wrinkles. If you have sensitive skin, you should consider how the peptides might affect it, as some of them may cause irritation. If your forehead lines are deep, then not even the best wrinkle cream may affect their appearance and you may have to consider cosmetic options instead, like Botox or Dysport.

Anti-aging creams are predominantly moisturiser-based cosmeceutical skin care products marketed with the promise of making the consumer look younger by reducing, masking or preventing signs of skin aging. These signs are laxity (sagging), rhytids (wrinkles), and photoaging, which includes erythema (redness), dyspigmentation (brown discolorations), solar elastosis (yellowing), keratoses (abnormal growths), and poor texture.[1]

Despite great demand, many anti-aging products and treatments have not been proven to give lasting or major positive effects. One study found that the best performing creams reduced wrinkles by less than 10% over 12 weeks, which is not noticeable to the human eye.[2] Another study found that cheap moisturisers were as effective as high-priced anti-wrinkle creams.[3][4] A 2009 study at Manchester University showed that some ingredients had an effect.[5][6]

Traditionally, anti-aging creams have been marketed towards women, but products specifically targeting men are increasingly common.[7]

With so many anti-aging products on the market, it’s hard to determine which formulas are really effective and worth your money. But here at Health, we take our skincare seriously and have collectively tried dozens of anti-aging creams, masks, and other treatments. Our staffers know which products live up to the wrinkle-fighting hype, so we asked them which products they can’t get enough of. Read on to learn which items our editors, who range from twentysomethings to fortysomethings, consider Holy Grail skincare picks.

Which? smoothes out the wrinkles on eye cream

Last year we tested 12 anti-wrinkle eye creams ranging in price from £3.21 to almost £49. After comparing 1,807 photos of 139 eye areas we discovered that the cheapest product worked just as well as the more expensive ones.

Dr Tamara Griffiths of the British Skin Foundation was involved in our research. ‘We need to have realistic expectations,’ she said. ‘A pricier eye cream can equal better packaging and more luxurious ingredients, but won’t necessarily work better.’

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A cosmetologist applying a face mask

Skin care is the range of practices that support skin integrity, enhance its appearance and relieve skin conditions. They can include nutrition, avoidance of excessive sun exposure and appropriate use of emollients. Practices that enhance appearance include the use of cosmetics, botulinum, exfoliation, fillers, laser resurfacing, microdermabrasion, peels, retinol therapy.[1] Skin care is a routine daily procedure in many settings, such as skin that is either too dry or too moist, and prevention of dermatitis and prevention of skin injuries.[2]

Allsharktankproducts showcases and reviews the products and businesses that have been featured on Shark Tank, the reality show in which dreams come to life and hopes are destroyed as brave entrepreneurs put their ideas, businesses, products, and emotional steel to the test. On this site you can browse through all the products on the homepage, or filter the products by season or product category using the options in the left sidebar.

If you’re looking for a Shark Tank product and have trouble finding it or can’t remember the product name, you can search for it using keywords like shoes, dog treat, or solar powered light. This site is a resource and directory for the numerous products and ideas that have been seen on Shark Tank.

As an entrepreneur who has created several products and taken them to market, I know the importance of getting as much exposure as possible, and I hope to support the Shark Tank entrepreneurs in their ventures. There are many successful products featured here as well as many that didn’t succeed. But all are worthy of our attention and respect. Pitching a business or product to the sharks and an audience of millions takes a lot of courage. These entrepreneurs had to battle countless competitors during rigorous auditions and multi-level applications to make it on Shark Tank.

The hit reality television show Shark Tank made it’s debut on August 9, 2009. The show was adapted from a popular series called Dragons’ Den that was first created in Japan and subsequently spread to 27 countries including the United Kingdom, Ireland, Russia, Australia, Spain, Afghanistan, and Croatia. In fact, sharks Robert Herjavec and Kevin O’Leary were both on the panel of investors on Dragons’ Den Canada. In 2008 Mark Burnett signed a deal with Sony, the show’s format holder, to make the American version of the series, which was re-branded as Shark Tank.